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大麻素CB1受体拮抗剂AM 251对大鼠食物摄入量的影响。

The effect of am 251, a cannabinoid CB1 receptor antagonist, on food intake in rats.

作者信息

Rutkowska Maria

机构信息

Department of Pharmacology, Medical University of Wrocław, 2 Radeckiego Str., PL 50-345 Wrocław, Poland.

出版信息

Acta Pol Pharm. 2004 Sep-Oct;61(5):401-3.

PMID:15747698
Abstract

The anorectic effect of AM 251 (N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-di-chlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide), a CB1 receptor antagonist, was studied in rats. AM 251 (0.5-2.0 mg/kg i.p.) significantly and dose-dependently reduced food intake in both free-feeding and food-deprived rats. The obtained results support the anorectic activity of CB1 receptors antagonists.

摘要

对CB1受体拮抗剂AM 251（N-（哌啶-1-基）-5-（4-碘苯基）-1-（2,4-二氯苯基）-4-甲基-1H-吡唑-3-甲酰胺）在大鼠中的厌食作用进行了研究。AM 251（腹腔注射0.5-2.0毫克/千克）显著且剂量依赖性地降低了自由进食和禁食大鼠的食物摄入量。所得结果支持CB1受体拮抗剂的厌食活性。

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