Schwartz Daniel M, Sandstedt Christian A, Chang Shiao H, Kornfield Julie A, Grubbs Robert H
Beckman Vision Center, Department of Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
Trans Am Ophthalmol Soc. 2004;102:67-72; discussion 72-4.
To determine whether digital spatial intensity patterns can be developed to effect precise in vitro correction of myopic, hyperopic, and astigmatic refractive errors in a silicone light-adjustable lens (LAL). Also, to determine whether a new spatial intensity pattern for "lock-in" is effective in vitro.
A digital interferometer/irradiation system was developed to irradiate LALs and measure the power change following irradiation. Light-adjustable lenses were mounted into a wet cell maintained at 35.0 +/- 0.5 degrees C (simulated ocular temperature) and allowed to equilibrate for a minimum of 2 hours. Ultraviolet light was then applied with spatial light intensity patterns to correct hyperopia, myopia, and astigmatism. Light-adjustable lenses were also treated to effect lock-in with a separate spatial light intensity pattern. Treated lenses were characterized for power change and optical quality. In the case of lock-in, exhaustive chemical extraction was also performed to determine the percentage of remaining macromer.
Appropriate digital irradiation spatial intensity patterns were created to develop nomograms for in vitro correction of myopia, hyperopia, and astigmatism in approximate 0.25 D steps. Power changes were reproducible and did not alter optical quality of the LALs. Further, lock-in dosing of the LALs did not alter optical quality or significantly change LAL power.
In vitro nomograms have been developed for a silicone LAL that permit precise correction of myopia, hyperopia, and astigmatism. Furthermore, a spatial light intensity pattern has been devised that effects lock-in without significantly altering LAL power or optical quality.
确定是否可以开发数字空间强度模式，以在硅酮光可调透镜（LAL）中实现对近视、远视和散光屈光不正的精确体外矫正。此外，确定一种用于“锁定”的新空间强度模式在体外是否有效。
开发了一种数字干涉仪/辐照系统，用于辐照LAL并测量辐照后的屈光力变化。将光可调透镜安装到保持在35.0±0.5摄氏度（模拟眼内温度）的湿盒中，并使其平衡至少2小时。然后应用具有空间光强度模式的紫外光来矫正远视、近视和散光。还使用单独的空间光强度模式对光可调透镜进行处理以实现锁定。对处理后的透镜进行屈光力变化和光学质量表征。在锁定的情况下，还进行了彻底的化学提取以确定剩余大分子单体的百分比。
创建了合适的数字辐照空间强度模式，以开发用于以约0.25 D步长在体外矫正近视、远视和散光的列线图。屈光力变化具有可重复性，并且未改变LAL的光学质量。此外，LAL的锁定剂量未改变光学质量或显著改变LAL屈光力。
已为硅酮LAL开发了体外列线图，可精确矫正近视、远视和散光。此外，还设计了一种空间光强度模式，可实现锁定，而不会显著改变LAL屈光力或光学质量。
