Sewnaik A, Hoorweg J J, Knegt P P, Wieringa M H, van der Beek J M H, Kerrebijn J D F
Erasmus Medisch Centrum, Department of Otolaryngology Head & Neck Surgery, DR Rotterdam, The Netherlands.
Clin Otolaryngol. 2005 Feb;30(1):52-7. doi: 10.1111/j.1365-2273.2004.00913.x.
To analyse different treatment strategies and treatment results of hypopharyngeal carcinoma in the Netherlands.
Retrospective study.
Eight head and neck centres in the Netherlands.
A total of 893 patients were treated between 1985 and 1994. Patients were mostly treated with radiotherapy alone, combined surgery and radiotherapy and surgery alone.
The 5-year survival for the whole group was 26%. The 5-year survival for patients treated with curative intention was 32% and treated with palliative intention was 5%. The 5-year disease-free survival after radiotherapy alone was 37%, after surgery alone 41% and after combined therapy 47%. The role of chemotherapy could not be investigated because of a small number of patients treated with chemotherapy in this period.
Combined therapy with surgery and radiotherapy has a better survival for patients with a hypopharyngeal carcinoma in comparison with radiotherapy alone. The N-stage is more important for the prognosis than the T-stage.
分析荷兰下咽癌的不同治疗策略及治疗结果。
回顾性研究。
荷兰的8个头颈中心。
1985年至1994年间共治疗893例患者。患者大多接受单纯放疗、手术联合放疗或单纯手术治疗。
全组5年生存率为26%。根治性治疗患者的5年生存率为32%，姑息性治疗患者的5年生存率为5%。单纯放疗后5年无病生存率为37%，单纯手术后为41%，联合治疗后为47%。由于这一时期接受化疗的患者数量较少，无法对化疗的作用进行研究。
与单纯放疗相比，手术联合放疗治疗下咽癌患者的生存率更高。N分期对预后的影响比T分期更重要。
