Tian Feng, Liu Ai-Lian
Center for Developmental Biology, Xinhua Hospital, Shanghai Second Medical University, Shanghai 200092, China.
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005 Feb;13(1):164-8.
During mammalian ontogeny, hematopoietic activity can be found in distinct anatomical sites, which con-tribute to primitive or definite hematopoiesis. The origin of the hematopoietic stem cell (HSC) has been a controversial issue in the field of hematopoiesis. It has long been believed that the origin derives from the extra-embryonic yolk sac. However, there is now considerable evidence that the first adult repopulating HSC is autonomously generated from a distinct region within the embryonic mesoderm, the aorta-gonad-mesonephros (AGM) region. This review describes the origin and precise location of HSC in the embryo and in AGM region, the hematopoietic microenvironment and the hematopoietic regulatory mechanisms in AGM region.
在哺乳动物个体发育过程中，造血活动可在不同的解剖部位发现，这些部位有助于原始造血或确定性造血。造血干细胞（HSC）的起源一直是造血领域中一个有争议的问题。长期以来，人们一直认为其起源于胚外卵黄囊。然而，现在有大量证据表明，第一个能够重建造血的成年造血干细胞是由胚胎中胚层内一个独特区域——主动脉-性腺-中肾（AGM）区自主产生的。本文综述了胚胎及AGM区造血干细胞的起源和精确位置、AGM区的造血微环境以及造血调控机制。
