Dölen Gül, Bear Mark F
Howard Hughes Medical Institute, The Picower Center for Learning and Memory, Department of Brain and Cognitive Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Neuron. 2005 Mar 3;45(5):642-4. doi: 10.1016/j.neuron.2005.02.021.
Fragile X syndrome is the most common heritable cause of mental retardation. Previous work has suggested that overactive signaling by group I metabotropic glutamate receptors (mGluRs) may be a mechanism underlying many of the disease symptoms. As a test of this theory, McBride et al. show that in a Drosophila model for Fragile X syndrome, treatment with mGluR antagonists can rescue short-term memory, courtship, and mushroom body defects.
脆性X综合征是智力迟钝最常见的遗传性病因。先前的研究表明，I型代谢型谷氨酸受体（mGluRs）信号过度活跃可能是许多疾病症状的潜在机制。作为对这一理论的验证，麦克布莱德等人表明，在脆性X综合征的果蝇模型中，用mGluR拮抗剂治疗可以挽救短期记忆、求偶行为和蘑菇体缺陷。
