成瘾中难以控制的动机：前额叶-伏隔核谷氨酸传递的一种病理状态。
Unmanageable motivation in addiction: a pathology in prefrontal-accumbens glutamate transmission.
作者信息
Kalivas P W, Volkow N, Seamans J
机构信息
Department of Neurosciences, Medical University of South Carolina, Charleston, SC 29465, USA.
出版信息
Neuron. 2005 Mar 3;45(5):647-50. doi: 10.1016/j.neuron.2005.02.005.
Prime diagnostic criteria for drug addiction include uncontrollable urges to obtain drugs and reduced behavioral responding for natural rewards. Cellular adaptations in the glutamate projection from the prefrontal cortex (PFC) to the nucleus accumbens have been discovered in rats withdrawn from cocaine that may underlie these cardinal features of addiction. A hypothesis is articulated that altered G protein signaling in the PFC focuses behavior on drug-associated stimuli, while dysregulated PFC-accumbens synaptic glutamate transmission underlies the unmanageable motivation to seek drugs.
药物成瘾的主要诊断标准包括无法控制的获取药物冲动以及对自然奖励的行为反应减少。在从可卡因戒断的大鼠中发现，前额叶皮层（PFC）到伏隔核的谷氨酸投射存在细胞适应性变化，这可能是成瘾这些主要特征的基础。本文提出了一个假说，即PFC中改变的G蛋白信号传导使行为集中于与药物相关的刺激，而PFC-伏隔核突触谷氨酸传递失调是寻求药物难以控制的动机的基础。
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