Zhang Guang-Xian, Yu Shuo, Li Yonghai, Ventura Elvira S, Gran Bruno, Rostami Abdolmohamad
Department of Neurology, Thomas Jefferson University, 300 JHN Building, 900 Walnut Street, Philadelphia, PA 19107, USA.
J Neuroimmunol. 2005 Apr;161(1-2):101-12. doi: 10.1016/j.jneuroim.2004.12.017.
The central role of T cells in the induction of tolerance to autoantigens has been well documented. However, the role of antigen-presenting cells (APCs) in this process is not yet fully understood. To better understand the contribution of APCs in tolerance, we studied the interaction of purified APCs and CD4(+) T cells in a model of intravenous (i.v.) tolerance to experimental autoimmune encephalomyelitis (EAE). As expected, we found that T cells were tolerized to the autoantigen after i.v. injection. However, purified APCs obtained from MOG-i.v.-treated mice were paradoxically immuno-stimulatory, as they induced a non-specific Th1-type response both in vitro and in vivo. We conclude that blocking such APC activation would enhance the effectiveness of tolerance induction.
T细胞在诱导自身抗原耐受性方面的核心作用已得到充分证明。然而，抗原呈递细胞（APC）在此过程中的作用尚未完全明确。为了更好地理解APC在耐受性中的作用，我们在实验性自身免疫性脑脊髓炎（EAE）静脉内（i.v.）耐受模型中研究了纯化的APC与CD4(+) T细胞之间的相互作用。正如预期的那样，我们发现静脉注射后T细胞对自身抗原产生了耐受性。然而，从接受MOG静脉注射治疗的小鼠中获得的纯化APC却具有反常的免疫刺激作用，因为它们在体外和体内均诱导了非特异性的Th1型反应。我们得出结论，阻断这种APC激活将增强耐受性诱导的效果。
