Askie Lisa M, Henderson-Smart David J, Jones Rachel A
Centre for Perinatal Health Services Research, Building DO2, University of Sydney, NSW 2006, Australia.
Early Hum Dev. 2005 Feb;81(2):135-42. doi: 10.1016/j.earlhumdev.2004.12.006. Epub 2005 Jan 16.
Chronic lung disease is common in extremely preterm infants born in Australasia. In 2002, 53% of surviving infants born before 28 weeks' gestation remained either oxygen-dependent or on other respiratory support at 36 weeks' postmenstrual age. In the first weeks of life oxygenation should be kept generally "lower", although what is the most appropriate level remains uncertain. During the mid-phase of the neonatal course, functional oxygen saturation levels around 90-95% probably confer the best benefit/risk balance. The most appropriate target saturation range for infants on home oxygen also remains uncertain. Definitive data to guide clinical practice is lacking regarding the use of postnatal corticosteroids, bronchodilators, and diuretics for either the treatment or prevention of chronic lung disease. Home oxygen programmes are effective in avoiding prolonged hospitalisation for infants with chronic lung disease, but require the coordination of a large, multidisciplinary team.
慢性肺部疾病在澳大利亚和新西兰出生的极早产儿中很常见。2002年，妊娠28周前出生的存活婴儿中，53%在孕龄36周时仍依赖氧气或接受其他呼吸支持。在生命的最初几周，一般应将氧合水平保持在“较低”水平，尽管最合适的水平仍不确定。在新生儿病程的中期，功能氧饱和度水平在90%-95%左右可能带来最佳的效益/风险平衡。家庭氧疗婴儿最合适的目标饱和度范围也仍不确定。关于使用产后皮质类固醇、支气管扩张剂和利尿剂治疗或预防慢性肺部疾病，缺乏指导临床实践的确切数据。家庭氧疗方案对于避免慢性肺部疾病婴儿长期住院有效，但需要一个大型多学科团队的协调。
