Tang Meng-Xing, Eckersley Robert J, Noble J Alison
Wolfson Medical Vision Laboratory, Department of Engineering Science, Oxford University, Oxford, UK.
Ultrasound Med Biol. 2005 Mar;31(3):377-84. doi: 10.1016/j.ultrasmedbio.2004.12.009.
It has previously been shown that the attenuation of ultrasound (US) by microbubble contrast agents is dependent on acoustic pressure (Chen et al. 2002). Although previous studies have modelled the pressure-dependence of attenuation in single bubbles, this paper investigates this subject by considering a bulk volume of bubbles together with other linear attenuators. Specifically, a new pressure-dependent attenuation model for an inhomogeneous volume of attenuators is proposed. In this model, the effect of the attenuation on US propagation is considered. The model was validated using experimental measurements on the US contrast agent Sonovue. The results indicate, at low acoustic pressures, a linear relationship between the attenuation of Sonovue, measured in dB, and the insonating acoustic pressure.
先前的研究表明，微泡造影剂对超声（US）的衰减取决于声压（Chen等人，2002年）。尽管先前的研究已经对单个气泡中衰减的压力依赖性进行了建模，但本文通过考虑大量气泡以及其他线性衰减器来研究这一主题。具体而言，提出了一种针对不均匀衰减器体积的新的压力依赖性衰减模型。在该模型中，考虑了衰减对超声传播的影响。使用对超声造影剂声诺维的实验测量对该模型进行了验证。结果表明，在低声压下，以分贝为单位测量的声诺维衰减与入射声压之间存在线性关系。
