Nilsson M, Norberg B, Hultdin J, Sandström H, Westman G, Lökk J
Department of Internal Medicine, University Hospital of Northern Sweden, SE-901 85 Umeå, Sweden.
Postgrad Med J. 2005 Mar;81(953):191-3. doi: 10.1136/pgmj.2004.020057.
Sweden is the only country in which oral high dose vitamin B12 has gained widespread use in the treatment of deficiency states.
The aim of the study was to describe prescribing patterns and sales statistics of vitamin B12 tablets and injections in Sweden 1990-2000.Design, setting, and sources: Official statistics of cobalamin prescriptions and sales were used.
The use of vitamin B12 increased in Sweden 1990-2000, mainly because of an increase in the use of oral high dose vitamin B12 therapy. The experience, in statistical terms a "total investigation", comprised 1,000,000 patient years for tablets and 750,000 patient years for injections. During 2000, 13% of residents aged 70 and over were treated with vitamin B12, two of three with the tablet preparation. Most patients in Sweden requiring vitamin B12 therapy have transferred from parenteral to oral high dose vitamin B12 since 1964, when the oral preparation was introduced.
The findings suggest that many patients in other post-industrial societies may also be suitable for oral vitamin B12 treatment.
瑞典是唯一一个口服高剂量维生素B12在治疗维生素缺乏状态方面得到广泛应用的国家。
本研究旨在描述1990 - 2000年瑞典维生素B12片剂和注射剂的处方模式及销售统计情况。设计、研究地点和资料来源：使用钴胺素处方和销售的官方统计数据。
1990 - 2000年瑞典维生素B12的使用量增加，主要是由于口服高剂量维生素B12疗法的使用增加。从统计学角度来看，这一“全面调查”的经验包括，片剂为100万个患者年，注射剂为75万个患者年。在2000年，70岁及以上的居民中有13%接受了维生素B12治疗，其中三分之二使用的是片剂制剂。自1964年引入口服制剂以来，瑞典大多数需要维生素B12治疗的患者已从肠外给药转为口服高剂量维生素B12治疗。
研究结果表明，其他后工业化社会的许多患者可能也适合口服维生素B12治疗。
