Ishida S, Hamada K, Yagi K, Seino M
National Epilepsy Center, Shizuoka Higashi Hospital, Japan.
Acta Neurol Scand. 1992 Feb;85(2):132-5. doi: 10.1111/j.1600-0404.1992.tb04012.x.
Dapsone, an antileprosy drug, was administered to rats with amygdala (AM)-kindled seizures or hippocampal (HIPP)-kindled seizures to elucidate its anticonvulsive efficacy. Adult male Wistar rats were subjected to kindling stimulations 2 weeks after electrode-implantation. The subjects were tested once a day for 7 successive days after inducing three generalized (stage 5) seizures to study the effects of dapsone. Dapsone had an inhibitory effect on stage 5 seizures at 12.50 mg/kg in the AM-kindled rats and at 6.25 mg/kg and 9.375 mg/kg in the HIPP-kindled rats. Thus, there was a distinct difference in the effective dose for generalized seizures between the AM-kindled rats and the HIPP-kindled rats. The inhibitory action of dapsone on stage 5 seizures may be due mainly to the elevation of the afterdischarge-triggering threshold at the stimulation site of the AM or HIPP. Such inhibitory action appears prominently at serum concentrations of about 13 micrograms/ml in AM-kindled rats and about 6 micrograms/ml in HIPP-kindled rats. The level of 6 micrograms/ml almost equals the therapeutic serum concentration of dapsone used in the treatment of leprosy.
氨苯砜是一种抗麻风病药物，被用于给患有杏仁核（AM）点燃性癫痫或海马体（HIPP）点燃性癫痫的大鼠用药，以阐明其抗惊厥疗效。成年雄性Wistar大鼠在电极植入2周后接受点燃刺激。在诱发三次全身性（5期）癫痫发作后，对实验对象连续7天每天进行一次测试，以研究氨苯砜的作用。氨苯砜对AM点燃的大鼠在剂量为12.50mg/kg时、对HIPP点燃的大鼠在剂量为6.25mg/kg和9.375mg/kg时对5期癫痫发作有抑制作用。因此，AM点燃的大鼠和HIPP点燃的大鼠在全身性癫痫发作的有效剂量上存在明显差异。氨苯砜对5期癫痫发作的抑制作用可能主要是由于AM或HIPP刺激部位的放电后触发阈值升高。这种抑制作用在AM点燃的大鼠血清浓度约为13微克/毫升、HIPP点燃的大鼠血清浓度约为6微克/毫升时明显出现。6微克/毫升的水平几乎等同于治疗麻风病时使用的氨苯砜治疗血清浓度。
