ETS相关基因1（ERG1）在前列腺癌转录组中频繁过表达。
Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome.
作者信息
Petrovics Gyorgy, Liu Aijun, Shaheduzzaman Syed, Furusato Bungo, Sun Chen, Chen Yongmei, Nau Martin, Ravindranath Lakshmi, Chen Yidong, Dobi Albert, Srikantan Vasantha, Sesterhenn Isabell A, McLeod David G, Vahey Maryanne, Moul Judd W, Srivastava Shiv
机构信息
Center for Prostate Disease Research (CPDR), Department of Surgery and US Military Cancer Institute, Uniformed Services University, Rockville, MD 20852, USA.
出版信息
Oncogene. 2005 May 26;24(23):3847-52. doi: 10.1038/sj.onc.1208518.
Transcription factors encoded by the ETS family of genes are central in integrating signals that regulate cell growth and differentiation, stress responses, and tumorigenesis. This study, analysing laser microdissected paired benign and malignant prostate epithelial cells from prostate cancer (CaP) patients (n=114; 228 specimen) by GeneChip and quantitative real-time RT-PCR, identifies ETS-related gene (ERG), a member of the ETS transcription factor family, as the most frequently overexpressed proto-oncogene in the transcriptome of malignant prostate epithelial cells. Combined quantitative expression analysis of ERG with two other genes commonly overexpressed in CaP, AMACR and DD3, revealed overexpression of at least one of these three genes in virtually all CaP specimen (54 of 55). Comprehensive evaluation of quantitative ERG1 expression with clinicopathological features also suggested that ERG1 expression level in prostate tumor cells relative to benign epithelial cells is indicator of disease-free survival after radical prostatectomy.
ETS基因家族编码的转录因子在整合调节细胞生长与分化、应激反应及肿瘤发生的信号过程中起核心作用。本研究通过基因芯片和定量实时逆转录聚合酶链反应，对来自前列腺癌（CaP）患者（n = 114；228个样本）的经激光显微切割的配对良性和恶性前列腺上皮细胞进行分析，确定ETS相关基因（ERG），即ETS转录因子家族的一个成员，为恶性前列腺上皮细胞转录组中最常过度表达的原癌基因。对ERG与另外两个在CaP中通常过度表达的基因AMACR和DD3进行联合定量表达分析，结果显示在几乎所有CaP样本（55个中的54个）中这三个基因至少有一个过度表达。对ERG1定量表达与临床病理特征进行综合评估还表明，前列腺肿瘤细胞中相对于良性上皮细胞的ERG1表达水平是根治性前列腺切除术后无病生存的指标。
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