Koshihara Moyuru, Masuyama Ritsuko, Uehara Mariko, Suzuki Kazuharu
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, 1-1-1 Sakuragaoka, Setagaya-ku, Tokyo 156-8502, Japan.
Biofactors. 2004;22(1-4):39-42. doi: 10.1002/biof.5520220107.
We investigated the effect of dietary calcium:phosphorus (Ca:P) ratio on bone mineralization and intestinal Ca absorption in ovariectomized (OVX) rat models of osteoporosis and sham-operated rats. Thirty 12-wk-old female Wistar rats were divided into three groups of OVX rats and three groups of sham rats. Thirty days after the adaptation period, OVX rats and sham rats were fed a diet formulated Ca:P, 1:0.5, 1:1 or 1:2 (each diet containing 0.5% Ca), respectively for 42 d. In both sham and OVX rats, serum osteocalcin, a marker of bone turnover, was increased by decreasing Ca:P ratio (1:2). In contrast, rats fed the Ca:P = 1:0.5 diet (dietary P restriction) suppressed the increased serum parathyroid hormone, osteocalcin and urinary deoxypyridinoline, and increased Ca absorption in both sham and OVX rats compared to the Ca:P = 1:1 and 1:2 diets. Especially, in OVX rats, the decreased bone mineral density of the fifth lumbar was also suppressed when rats were fed the Ca:P = 1:0.5 diet. These results indicated that the elevation of dietary Ca:P ratio may inhibit bone loss and increase intestinal Ca absorption in OVX rats.
我们研究了饮食中钙磷（Ca:P）比例对骨质疏松卵巢切除（OVX）大鼠模型和假手术大鼠骨矿化及肠道钙吸收的影响。将30只12周龄雌性Wistar大鼠分为三组OVX大鼠和三组假手术大鼠。适应期30天后，OVX大鼠和假手术大鼠分别喂食钙磷比为1:0.5、1:1或1:2（每种饮食含0.5%钙）的饲料，持续42天。在假手术和OVX大鼠中，骨转换标志物血清骨钙素均随钙磷比降低（1:2）而升高。相比之下，与钙磷比为1:1和1:2的饲料相比，喂食钙磷比=1:0.5饲料（饮食磷限制）的大鼠，假手术和OVX大鼠血清甲状旁腺激素、骨钙素及尿脱氧吡啶啉升高受到抑制，钙吸收增加。特别是，在OVX大鼠中，喂食钙磷比=1:0.5饲料时，第五腰椎骨密度降低也受到抑制。这些结果表明，提高饮食钙磷比可能抑制OVX大鼠的骨质流失并增加肠道钙吸收。
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