Koshihara Moyuru, Katsumata Shin-Ichi, Uehara Mariko, Suzuki Kazuharu
Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
Biosci Biotechnol Biochem. 2005 May;69(5):1025-8. doi: 10.1271/bbb.69.1025.
We investigated the effects of dietary phosphorus (P) intake on the bone mineralization and calcium (Ca) absorption in adult female rats. Fifteen 16-wk-old female Wistar rats were divided into three groups, and respectively fed a low-P diet containing 0.15% P (LP), a control diet containing 0.5% P (C), and a high-P diet containing 1.5% P (HP) for 42 d. The apparent Ca absorption was significantly increased with decreasing dietary P level. The serum parathyroid hormone concentration was significantly lower in the LP group than in the C and HP groups. The serum osteocalcin concentration and urinary excretion of deoxypyridinoline were significantly higher in the HP groups than in the LP and C groups. The bone mineral density of the fifth lumbar vertebra was significantly increased with decreasing dietary P level. These results indicate that the low-P diet increased Ca absorption, this being effective for bone mineralization in adult female rats.
我们研究了膳食磷（P）摄入量对成年雌性大鼠骨矿化和钙（Ca）吸收的影响。将15只16周龄的雌性Wistar大鼠分为三组，分别给予含0.15% P的低磷饮食（LP）、含0.5% P的对照饮食（C）和含1.5% P的高磷饮食（HP），持续42天。随着膳食磷水平的降低，表观钙吸收显著增加。LP组血清甲状旁腺激素浓度显著低于C组和HP组。HP组血清骨钙素浓度和脱氧吡啶啉尿排泄量显著高于LP组和C组。随着膳食磷水平的降低，第五腰椎的骨密度显著增加。这些结果表明，低磷饮食增加了钙的吸收，这对成年雌性大鼠的骨矿化有效。
