Ohmura Takeshi, Umekita Nobutaka, Ohkubo Takao, Tanaka Souichi, Maeshiro Tsuyoshi, Matsuo Satoru, Miyamoto Sachio, Inoue Satoru, Kitamura Masatsugu
Dept of Surgery, Tokyo Metropolitan Bokuto Hospital.
Gan To Kagaku Ryoho. 2005 Feb;32(2):239-41.
We report a patient for whom systemic chemotherapy using gemcitabine was effective against local recurrence of pancreatic cancer. A 58-year-old man underwent pancreatoduodenectomy for a pancreatic head cancer. The diagnosis was Stage IVb poorly-differentiated tubular adenocarcinoma, scirrhous type, pT4, PL (+), P0, H0, pN2. However, after 21 months, gastrointestinal bleeding occurred. Gastroscopy and CT examination revealed a mass at the cut-end of the pancreas invading the stomach. The serum CA19-9 level was found to be elevated. Systemic chemotherapy was performed with a regimen of gemcitabine 1,000 mg/m2/week for 2 weeks, followed by a week rest. The recurrent tumor in the stomach disappeared, and the mass at the cut-end of the pancreas became small. The serum CA 19-9 level regained the normal value. Two years after the diagnosis of recurrence, he returned to work, and his chemotherapy is being continued as an outpatient.
我们报告了一例使用吉西他滨进行全身化疗对胰腺癌局部复发有效的患者。一名58岁男性因胰头癌接受了胰十二指肠切除术。诊断为IVb期低分化管状腺癌，硬癌型，pT4，PL(+)，P0，H0，pN2。然而，21个月后，出现了胃肠道出血。胃镜和CT检查显示胰腺切端有肿块侵犯胃。发现血清CA19-9水平升高。采用吉西他滨1000mg/m²/周的方案进行全身化疗，共2周，随后休息1周。胃内的复发肿瘤消失，胰腺切端的肿块变小。血清CA19-9水平恢复正常。复发诊断两年后，他重返工作岗位，目前作为门诊患者继续接受化疗。
