水蚤基因组数据库：水蚤基因组数据库。
wFleaBase: the Daphnia genome database.
作者信息
Colbourne John K, Singan Vasanth R, Gilbert Don G
机构信息
Center for Genomics and Bioinformatics, Indiana University, Bloomington, Indiana, USA.
出版信息
BMC Bioinformatics. 2005 Mar 7;6:45. doi: 10.1186/1471-2105-6-45.
BACKGROUND
wFleaBase is a database with the necessary infrastructure to curate, archive and share genetic, molecular and functional genomic data and protocols for an emerging model organism, the microcrustacean Daphnia. Commonly known as the water-flea, Daphnia's ecological merit is unequaled among metazoans, largely because of its sentinel role within freshwater ecosystems and over 200 years of biological investigations. By consequence, the Daphnia Genomics Consortium (DGC) has launched an interdisciplinary research program to create the resources needed to study genes that affect ecological and evolutionary success in natural environments.
DISCUSSION
These tools include the genome database wFleaBase, which currently contains functions to search and extract information from expressed sequenced tags, genome survey sequences and full genome sequencing projects. This new database is built primarily from core components of the Generic Model Organism Database project, and related bioinformatics tools.
SUMMARY
Over the coming year, preliminary genetic maps and the nearly complete genomic sequence of Daphnia pulex will be integrated into wFleaBase, including gene predictions and ortholog assignments based on sequence similarities with eukaryote genes of known function. wFleaBase aims to serve a large ecological and evolutionary research community. Our challenge is to rapidly expand its content and to ultimately integrate genetic and functional genomic information with population-level responses to environmental challenges. URL: http://wfleabase.org/.
背景
wFleaBase是一个数据库，具备必要的基础设施，用于管理、存档和共享一种新兴模式生物——微型甲壳动物水蚤的遗传、分子和功能基因组数据及实验方案。水蚤通常被称为水跳蚤，其生态价值在后生动物中无与伦比，这主要是因为它在淡水生态系统中的哨兵作用以及超过200年的生物学研究历史。因此，水蚤基因组学联盟（DGC）启动了一项跨学科研究计划，以创建研究在自然环境中影响生态和进化成功的基因所需的资源。
讨论
这些工具包括基因组数据库wFleaBase，它目前具备从表达序列标签、基因组勘测序列和全基因组测序项目中搜索和提取信息的功能。这个新数据库主要由通用模式生物数据库项目的核心组件及相关生物信息学工具构建而成。
总结
在未来一年里，水蚤的初步遗传图谱和几近完整的基因组序列将被整合到wFleaBase中，包括基于与已知功能的真核生物基因序列相似性的基因预测和直系同源物分配。wFleaBase旨在服务广大生态和进化研究群体。我们面临的挑战是迅速扩充其内容，并最终将遗传和功能基因组信息与种群对环境挑战的反应整合起来。网址：http://wfleabase.org/
Zotero 插件