Romualdi Alessandro, Siddiqui Roman, Glöckner Gernot, Lehmann Rüdiger, Sühnel Jürgen
Biocomputing Group, Institute of Molecular Biotechnology, 07745 Jena, Germany.
Bioinformatics. 2005 Sep 15;21(18):3669-71. doi: 10.1093/bioinformatics/bti606. Epub 2005 Aug 2.
GenColors is a new web-based software/database system aimed at an improved and accelerated annotation of prokaryotic genomes, considering information on related genomes and making extensive use of genome comparison. It offers a seamless integration of data from ongoing sequencing projects and annotated genomic sequences obtained from GenBank. The genome comparison tools determine, for example, best-bidirectional hits, gene conservation, syntenies and gene core sets. Swiss-Prot/TrEMBL hits allow annotations in an effective manner. To further support the annotation base-specific quality data can also be displayed if available. With GenColors dedicated genome browsers containing a group of related genomes can be easily set up and maintained. It has been efficiently used for Borrelia garinii and is currently applied to various ongoing genome projects.
Detailed information on GenColors is available at http://gencolors.imb-jena.de. Online usage of GenColors-based genome browsers is the preferred application mode. The system is also available upon request for local installation.
GenColors是一个基于网络的新型软件/数据库系统，旨在改进和加速原核生物基因组注释，考虑相关基因组信息并广泛利用基因组比较。它能无缝整合来自正在进行的测序项目的数据以及从GenBank获得的注释基因组序列。基因组比较工具可确定，例如，最佳双向匹配、基因保守性、共线性和基因核心集。Swiss-Prot/TrEMBL匹配可有效地进行注释。若有可用的特定于注释库的质量数据，也可显示以进一步支持注释。使用GenColors可以轻松设置和维护包含一组相关基因组的专用基因组浏览器。它已有效地用于莱姆病螺旋体，目前正应用于各种正在进行的基因组项目。
有关GenColors的详细信息可在http://gencolors.imb-jena.de获取。基于GenColors的基因组浏览器的在线使用是首选应用模式。该系统也可根据要求进行本地安装。
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