Kalderon Daniel
Department of Biological Sciences, Columbia University, 1212 Amsterdam Avenue, New York NY 10027, USA.
Curr Biol. 2005 Mar 8;15(5):R175-8. doi: 10.1016/j.cub.2005.02.046.
Arrestins are best known for terminating signaling by G protein coupled receptors. New binding, localization and genetic studies suggest that Arrestins may also participate in the transduction of Hedgehog signals by the seven transmembrane domain protein, Smoothened.
抑制蛋白最为人所知的是通过G蛋白偶联受体终止信号传导。新的结合、定位和遗传学研究表明,抑制蛋白也可能参与七跨膜结构域蛋白“平滑化”所介导的刺猬信号转导。