刺猬信号通路：利用受体比率测量配体浓度。
Hedgehog signaling: measuring ligand concentrations with receptor ratios.
作者信息
Briscoe James
机构信息
Developmental Neurobiology, National Institute for Medical Research The Ridgeway, Mill Hill, London, NW7 1AA, UK.
出版信息
Curr Biol. 2004 Oct 26;14(20):R889-91. doi: 10.1016/j.cub.2004.09.071.
PMID:15498480
Abstract
How the binding of Hedgehog to its receptor, Patched, initiates signaling is poorly understood. A recent study suggests a mechanism by which the ratio of unliganded to liganded Patched determines the cellular response.
摘要
刺猬索尼克蛋白（Hedgehog）与其受体帕奇蛋白（Patched）的结合是如何启动信号传导的，目前还知之甚少。最近的一项研究提出了一种机制，即未结合配体的帕奇蛋白与结合配体的帕奇蛋白的比例决定了细胞反应。
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