[健康老年人松果体褪黑素合成功能的昼夜节律]

[Circadian rhythms of pineal gland melatonin-forming function in healthy elderly people].

作者信息

Korkushko O V, Khavinson V Kh, Shatilo V B, Magdich L V, Labunets I F

出版信息

Adv Gerontol. 2004;15:70-5.

Abstract

Circadian rhythms of pineal gland melatonin-forming function were studied in healthy elderly people (n=31, age range 60-74 years). The blood plasma melatonin concentration was determined by means of radioimmune method at 3.00, 9.00, 15.00 and 21.00. The study revealed two types of circadian rhythms of plasma melatonin concentration: a high-amplitude (29%) and a low-amplitude (71%) ones. The high-amplitude rhythm of melatonin-forming pineal gland function was observed in elderly people with a higher physical working ability and a lower functional age of cardiovascular system. It is advisable to conduct the correction of pineal gland melatonin-forming function in elderly people with low-amplitude circadian rhythm of plasma melatonin concentration.

摘要

对31名健康老年人（年龄范围60 - 74岁）的松果体褪黑素生成功能的昼夜节律进行了研究。采用放射免疫法在凌晨3点、上午9点、下午3点和晚上9点测定血浆褪黑素浓度。研究揭示了血浆褪黑素浓度的两种昼夜节律类型：高振幅（29%）和低振幅（71%）。在身体工作能力较高且心血管系统功能年龄较低的老年人中观察到了褪黑素生成松果体功能的高振幅节律。对于血浆褪黑素浓度昼夜节律为低振幅的老年人，建议对松果体褪黑素生成功能进行校正。