Kolesnikova L A
Genetika. 1997 Aug;33(8):1144-8.
Circadian dynamics of biosynthetic activity in pineal glands of adult relatively wild and domesticated silver fox females was studied beyond the reproductive season using radioimmune and fluorometric methods. The level of melatonin, the principal pineal hormone; activities of enzymes controlling its biosynthesis; the level of its precursor and one of its metabolites, as well as those of neurotransmitters involved in the regulation of biosynthesis exhibited more or less pronounced circadian changes. The concentration of melatonin in the pineal gland at night was considerably higher in domesticated foxes than in relatively wild ones. The most likely reason for the elevated concentration of melatonin at night is its slow secretion from the pineal glands of domesticated foxes, because its concentration in plasma does not differ from that in relatively wild animals. The results obtained suggest that selection for domestic behavior has affected the adrenergic mechanism of regulation of pineal gland rhythms, as well as other functions of sympathetic divisions of the central nervous system.
在繁殖季节之外，使用放射免疫和荧光测定方法研究了成年相对野生和驯化的银狐雌性松果体生物合成活动的昼夜节律。褪黑素（主要的松果体激素）水平、控制其生物合成的酶活性、其前体和一种代谢物的水平，以及参与生物合成调节的神经递质的水平，都或多或少呈现出明显的昼夜变化。夜间驯化狐狸松果体中褪黑素的浓度明显高于相对野生的狐狸。夜间褪黑素浓度升高最可能的原因是其从驯化狐狸的松果体中分泌缓慢，因为其血浆中的浓度与相对野生动物的浓度没有差异。获得的结果表明，对家养行为的选择影响了松果体节律调节的肾上腺素能机制以及中枢神经系统交感神经部分的其他功能。
