Huang Xing, Hu Li-Quan, Tian Bin-Qun
Department of Urology, Zhongnan Hospital, Wuhan University, Wuhan, Hubei 430071, China.
Zhonghua Nan Ke Xue. 2005 Feb;11(2):98-100.
To investigate the effects of growth hormone (GH) on the erectile function and the number of neuronal nitric oxide synthase (nNOS) -containing nerve fibers in the penis of aged rats.
Twenty-four aged male SD rats (18 months) were randomized into 2 groups: GH intervention group and control group. After four and eight weeks, a half of each group were selected and tested for erectile function after apomorphine (APO) injection and then sacrificed for the detection of nNOS-containing nerve fibers in the penis by streptavidin-peroxidase conjugated method (SP method).
After four weeks, the erectile function and the number of nNOS-containing nerve fibers showed no significant difference between the GH intervention group and the control group (P > 0.05). After eight weeks, the erection frequency was significantly different (P < 0.05) between the two groups, while the erection rate was not. The number of nNOS-containing nerve fibers in the GH intervention group was significantly larger than that in the control group (P < 0.01).
GH enhances the regeneration of nNOS-containing nerve fibers in the penis and improves the erectile function of the aged rat.
探讨生长激素（GH）对老年大鼠阴茎勃起功能及含神经元型一氧化氮合酶（nNOS）神经纤维数量的影响。
将24只18月龄的老年雄性SD大鼠随机分为2组：GH干预组和对照组。4周和8周后，每组各选取一半大鼠，注射阿扑吗啡（APO）后检测勃起功能，然后处死，采用链霉亲和素-过氧化物酶偶联法（SP法）检测阴茎中含nNOS的神经纤维。
4周后，GH干预组与对照组的勃起功能及含nNOS神经纤维数量无显著差异（P>0.05）。8周后，两组间勃起频率有显著差异（P<0.05），而勃起率无差异。GH干预组中含nNOS神经纤维数量显著多于对照组（P<0.01）。
GH可促进老年大鼠阴茎中含nNOS神经纤维的再生，改善其勃起功能。
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