1例腭部表现为黑色素沉着的黏液表皮样癌。
A case of mucoepidermoid carcinoma with melanin pigmentation manifested in the palate.
作者信息
Sekine Joji, Anami Masanobu, Fujita Shuichi, Vieth Michael, Inokuchi Tsugio
机构信息
Division of Oral and Maxillofacial Surgical Reconstruction and Functional Restoration, Department of Developmental and Reconstructive Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
出版信息
Virchows Arch. 2005 Apr;446(4):460-2. doi: 10.1007/s00428-005-1213-7. Epub 2005 Mar 9.
This paper describes the first documented case of mucoepidermoid carcinoma (MEC) with melanin pigmentation manifested in the palate. Histopathological sections showed a neoplasm composed of epidermoid, mucous-producing and intermediate cells. Numerous large cells contained dark pigmented materials. Fontana Masson staining revealed dendritic melanocytes and melanin granules. HMB-45, Melan A and S-100 protein were all positive for melanocytes. Histopathological examination was not typical for malignant melanoma; the lesion was diagnosed as a low-grade MEC with melanin pigmentation.
本文描述了首例有文献记载的发生于腭部的伴有黑色素沉着的黏液表皮样癌（MEC）病例。组织病理学切片显示肿瘤由表皮样细胞、黏液生成细胞和中间细胞组成。大量大细胞含有深色色素物质。Fontana Masson染色显示有树突状黑素细胞和黑色素颗粒。HMB - 45、Melan A和S - 100蛋白对黑素细胞均呈阳性。组织病理学检查并非典型的恶性黑色素瘤；该病变被诊断为伴有黑色素沉着的低级别MEC。
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