[化学发光法测定双嘧达莫]

[Chemiluminescence method for determination of dipyridamole].

作者信息

Rao Zhi-ming, Zhang Wang-hua, Li Qiu-zhong, Xie Guo-ping, Yang Hui-qin

机构信息

Department of Chemistry, Zhangzhou Normal College, Zhangzhou, China.

出版信息

Guang Pu Xue Yu Guang Pu Fen Xi. 2004 Mar;24(3):278-80.

PMID:15759974

Abstract

A new system for the determination of dipyridamole with flow injection chemiluminescence was described. It is based on the chemiluminescence reaction of dipyridamole-potassium permanganate with rhodamine B. Tween-80 was found to be an enhancer of the chemiluminescence reaction. A method based on the enhanced chemiluminescence for dipyridamole determination has been developed. The method has high sensitivity, selectivity and good repeatability with a linear concentration range of 5.0 x 10(-8) - 5.0 x 10(-5) g x mL(-1), a detection limit of 1.7 x 10(-8) g x mL(-1) and a RSD of 1.1% (n = 11, cs = 1.0 x 10(-6) g x mL(-1)).

摘要

描述了一种用于测定双嘧达莫的流动注射化学发光新系统。它基于双嘧达莫 - 高锰酸钾与罗丹明B的化学发光反应。发现吐温 - 80是该化学发光反应的增强剂。已开发出一种基于增强化学发光法测定双嘧达莫的方法。该方法具有高灵敏度、选择性和良好的重复性，线性浓度范围为5.0×10⁻⁸ - 5.0×10⁻⁵ g·mL⁻¹，检测限为1.7×10⁻⁸ g·mL⁻¹，相对标准偏差为1.1%（n = 11，cs = 1.0×10⁻⁶ g·mL⁻¹）。