氯化钾和阳离子药物对κ-卡拉胶基质的溶胀、侵蚀及释放的影响。
Effect of potassium chloride and cationic drug on swelling, erosion and release from kappa-carrageenan matrices.
作者信息
Naim Syed, Samuel Betty, Chauhan Bhaskar, Paradkar Anant
机构信息
Department of Pharmaceutics, Bharati Vidyapeeth Deemed University, Poona College of Pharmacy, Erandwane, Pune-411038, Maharashtra, India.
出版信息
AAPS PharmSciTech. 2004 Mar 9;5(2):e25. doi: 10.1208/pt050225.
The basic objective of this work was to study the effect of model cationic drug metformin HCl on swelling and erosion and, in turn, the release of KCl and drug itself, from the kappa-carrageenan matrices. Water uptake by the matrix up to 2 hours was found to increase with KCl concentration from the plain matrix. Erosion was not affected by concentration of KCl. Incorporation of drug favors water uptake, but in presence of KCl it was found to be reduced. Drug-containing matrices have shown higher release of KCl as compared with plain batches. Drug release was retarded as KCl concentration increased up to 5%, above which the reduced cohesivity of the matrix caused increase in drug release.
这项工作的基本目标是研究模型阳离子药物盐酸二甲双胍对κ-卡拉胶基质的溶胀和侵蚀的影响，进而研究氯化钾和药物本身从该基质中的释放情况。发现直至2小时，基质的吸水量随氯化钾浓度的增加而高于空白基质。侵蚀不受氯化钾浓度的影响。药物的加入有利于吸水量增加，但在有氯化钾存在的情况下，吸水量有所降低。与空白批次相比，含药基质显示出更高的氯化钾释放量。随着氯化钾浓度增加至5%，药物释放受到抑制，超过该浓度后，基质内聚力降低导致药物释放增加。
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