铜（I）催化的1-烷基烯丙基硅烷与α-亚氨基酯的对映选择性[3 + 2]环加成反应：脱氢脯氨酸衍生物的不对称合成
Cu(I)-catalyzed enantioselective [3 + 2] cycloaddition reaction of 1-alkylallenylsilane with alpha-imino ester: asymmetric synthesis of dehydroproline derivatives.
作者信息
Daidouji Kazunori, Fuchibe Kohei, Akiyama Takahiko
机构信息
Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
出版信息
Org Lett. 2005 Mar 17;7(6):1051-3. doi: 10.1021/ol047343c.
PMID:15760136
Abstract
[reaction: see text] The catalytic, enantioselective [3 + 2] cycloaddition reaction of 1-alkyl-substituted allenylsilanes with alpha-imino ester has been achieved by means of [Cu(MeCN)(4)]BF(4)/(R)-DM-SEGPHOS catalyst to afford silyl-substituted dehydroproline derivatives in high yields and enantioselectivities.
摘要
[反应：见正文] 通过[Cu(MeCN)₄]BF₄/(R)-DM-SEGPHOS催化剂实现了1-烷基取代的烯丙基硅烷与α-亚氨基酯的催化对映选择性[3+2]环加成反应，以高收率和对映选择性得到硅烷基取代的脱氢脯氨酸衍生物。
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