手性银酰胺催化的 α-氨基膦酸酯与烯烃的对映选择性[3+2]环加成反应。
Chiral silver amide-catalyzed enantioselective [3 + 2] cycloaddition of alpha-aminophosphonates with olefins.
机构信息
Department of Chemistry, School of Science, The University of Tokyo, and the HFRE Division, ERATO, Japan Science Technology Agency, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
出版信息
J Am Chem Soc. 2010 Mar 17;132(10):3262-3. doi: 10.1021/ja100101n.
PMID:20163117
Abstract
The first catalytic asymmetric [3 + 2] cycloadditions of Schiff bases of alpha-aminophosphonates with olefins have been developed. Chiral silver amide complexes bearing (R)-DTBM-SEGPHOS worked well as catalysts for the first time, and proline phosphonic analogues were obtained in high yields with excellent exo- and enantioselectivities.
摘要
首次发展了手性亚膦酸酯烯胺Schiff 碱与烯烃的[3+2]环加成反应的催化不对称反应。手性银酰胺配合物（R）-DTBM-SEGPHOS 首次作为催化剂表现良好，脯氨酸膦酸类似物以高产率和优异的 exo-和对映选择性获得。
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