嘌呤2'-脱氧核苷和核苷的铃木交叉偶联反应中的氟、烷硫基和烷磺酰基离去基团。
Fluoro, alkylsulfanyl, and alkylsulfonyl leaving groups in suzuki cross-coupling reactions of purine 2'-deoxynucleosides and nucleosides.
作者信息
Liu Jiangqiong, Robins Morris J
机构信息
Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602-5700, USA.
出版信息
Org Lett. 2005 Mar 17;7(6):1149-51. doi: 10.1021/ol050063s.
PMID:15760161
Abstract
[reaction: see text] Protected 2'-deoxynucleoside and nucleoside derivatives of 6-fluoropurine, 6-(3-methylbutyl)sulfanylpurine, and 6-(3-methylbutyl)ylsulfonylpurine undergo nickel- or palladium-mediated C-C cross-coupling with arylboronic acids to give good yields of 6-arylpurine products.
摘要
[反应：见正文] 6-氟嘌呤、6-(3-甲基丁基)硫基嘌呤和6-(3-甲基丁基)磺酰基嘌呤的受保护2'-脱氧核苷和核苷衍生物与芳基硼酸发生镍或钯介导的C-C交叉偶联反应，以良好的产率得到6-芳基嘌呤产物。
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