Capek Petr, Pohl Radek, Hocek Michal
Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, CZ-16610 Prague 6, Czech Republic.
J Org Chem. 2004 Nov 12;69(23):7985-8. doi: 10.1021/jo048812r.
(Purin-6-yl)alanines, a new class of amino acid-nucleobase conjugates, were synthesized by palladium-catalyzed cross-coupling reactions of protected iodozincalanines with 6-iodopurines (9-Bn-6-iodopurine and 9-THP-6-iodopurine as well as acyl-protected 6-iodopurine ribonucleoside and 2-deoxyribonucleoside). Free purine base and nucleosides bearing alanine in position 6 were obtained after complete deprotection of the products of cross-coupling reactions.
（嘌呤 -6- 基）丙氨酸是一类新型的氨基酸 - 核苷酸碱基共轭物，通过钯催化的保护碘代锌丙氨酸与 6-碘嘌呤（9-苄基 -6-碘嘌呤、9-四氢吡喃基 -6-碘嘌呤以及酰基保护的 6-碘嘌呤核糖核苷和 2-脱氧核糖核苷）的交叉偶联反应合成。交叉偶联反应产物完全脱保护后，得到了在 6 位带有丙氨酸的游离嘌呤碱和核苷。
