Zhang Rui, Chandrasena R Esala P, Martinez Enrique, Horner John H, Newcomb Martin
Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607, USA.
Org Lett. 2005 Mar 17;7(6):1193-5. doi: 10.1021/ol050296j.
[reaction: see text] Compound I is the heme-iron(IV)-oxo porphyrin radical cation formed in peroxidase and catalase enzymes by reaction with hydrogen peroxide. As an alternative to chemical oxidations of porphyrin-iron(III) species, various compound I species were produced by 355 nm laser flash photolysis photooxidation of the corresponding compound II species, porphyrin-iron(IV)-oxo derivatives. The method is demonstrated by production and kinetic studies of the compound I species from 5,10,15,20-tetrakis(pentafluorophenyl)porphyrin-iron, from horseradish peroxidase, and from wild-type horse skeletal myoglobin.
[反应：见正文] 化合物I是过氧化物酶和过氧化氢酶与过氧化氢反应形成的血红素-铁（IV）-氧代卟啉自由基阳离子。作为卟啉-铁（III）物种化学氧化的替代方法，通过对相应的化合物II物种（卟啉-铁（IV）-氧代衍生物）进行355nm激光闪光光解光氧化产生了各种化合物I物种。通过对来自5,10,15,20-四（五氟苯基）卟啉-铁、辣根过氧化物酶和野生型马骨骼肌肌红蛋白的化合物I物种进行制备和动力学研究，证明了该方法。
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