Taillier Catherine, Gille Barbara, Bellosta Véronique, Cossy Janine
Laboratoire de Chimie Organique, associé au CNRS, ESPCI, 10 rue Vauquelin, 75231 Paris Cedex 05, France.
J Org Chem. 2005 Mar 18;70(6):2097-108. doi: 10.1021/jo048115z.
[structure: see text] The total synthesis of (+)-zoapatanol utilizing an intramolecular Horner-Wadsworth-Emmons olefination and an enantioselective Sharpless dihydroxylation as the key steps has been achieved. An advanced oxepene intermediate has been obtained by applying a ring-closing metathesis to an unsaturated enol ether.
[结构：见正文] 以分子内霍纳-沃兹沃思-埃蒙斯烯化反应和对映选择性夏普莱斯双羟基化反应为关键步骤，实现了（+）-佐帕他醇的全合成。通过将闭环复分解反应应用于不饱和烯醇醚，得到了一种高级氧杂环庚三烯中间体。
