Ng L L, Garrido M C, Davies J E, Brochwicz-Lewinski M J, Tan L B
Department of Pharmacology & Therapeutics, Leicester Royal Infirmary.
Br J Clin Pharmacol. 1992 Mar;33(3):329-32. doi: 10.1111/j.1365-2125.1992.tb04046.x.
Cellular Mg2+ depletion has been reported in patients on long term diuretic therapy. We therefore measured lymphocyte free Mg2+ concentrations in patients with congestive cardiac failure treated with loop diuretics or a frusemide/amiloride mixture (Frumil) and compared them with control subjects. There was no correlation between lymphocyte free Mg2+ levels and plasma Mg2+ concentrations. Patients treated with loop diuretics did not show lymphocyte intracellular free Mg2+ depletion compared with normal controls, and those on Frumil showed higher intracellular free Mg2+ levels than normal.
据报道，长期接受利尿治疗的患者存在细胞内镁离子缺乏的情况。因此，我们测量了接受袢利尿剂或速尿/氨氯吡咪合剂（Frumil）治疗的充血性心力衰竭患者淋巴细胞中的游离镁离子浓度，并将其与对照组进行比较。淋巴细胞中的游离镁离子水平与血浆镁离子浓度之间没有相关性。与正常对照组相比，接受袢利尿剂治疗的患者并未出现淋巴细胞内游离镁离子缺乏的情况，而服用Frumil的患者细胞内游离镁离子水平高于正常水平。
