Fenster L, Windham G C, Swan S H, Epstein D M, Neutra R R
Special Epidemiological Studies Program, California Department of Health Services, Berkeley 94704.
Epidemiology. 1992 Mar;3(2):120-4. doi: 10.1097/00001648-199203000-00009.
A recent case-control study of 1,926 women found a slightly increased risk of spontaneous abortion associated with reported consumption of tapwater and a decreased risk with reported consumption of bottled water. In a case-control study of spontaneous abortion designed to examine the consistency of prenatal exposure reporting, the association of spontaneous abortion with tap or bottled water consumption was also examined. Cases of spontaneous abortion (N = 100) were ascertained from hospital pathology reports, and pregnant controls (N = 200) were obtained from obstetrical appointment logs. Subjects were first interviewed approximately 24 weeks after their last menstrual period and again approximately 48 weeks after their last menstrual period. Neither an increased risk for spontaneous abortion associated with consumption of tapwater nor a protective effect for consumption of bottled water was observed. Changes in reporting of tapwater consumption from the first to the second interview suggest the possibility of differential reporting in cases and controls. There was no evidence suggesting biased reporting of bottled water consumption.
最近一项针对1926名女性的病例对照研究发现，报告饮用自来水与自然流产风险略有增加相关，而报告饮用瓶装水则与风险降低相关。在一项旨在检查产前暴露报告一致性的自然流产病例对照研究中，也对自然流产与饮用自来水或瓶装水之间的关联进行了研究。自然流产病例（N = 100）通过医院病理报告确定，怀孕对照组（N = 200）从产科预约记录中获取。受试者在最后一次月经周期后约24周首次接受访谈，在最后一次月经周期后约48周再次接受访谈。未观察到饮用自来水与自然流产风险增加相关，也未观察到饮用瓶装水有保护作用。从第一次访谈到第二次访谈，自来水消费报告的变化表明病例组和对照组可能存在差异报告。没有证据表明瓶装水消费报告存在偏差。
