丙咪嗪对慢性强迫游泳应激大鼠不动时间的影响。
Influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats.
作者信息
Kitamura Yoshihisa, Araki Hiroaki, Nagatani Tadashi, Takao Katsuyuki, Shibata Kazuhiko, Gomita Yutaka
机构信息
Department of Hospital Pharmacy, Okayama University Medical School, Okayama 700 8558, Japan.
出版信息
Acta Med Okayama. 2004 Dec;58(6):271-4. doi: 10.18926/AMO/32092.
We studied the influence of imipramine on the duration of immobility in chronic forced-swim-stressed rats. Both single and chronic administration of imipramine potently shortened immobility in naive rats during forced-swim testing. However, chronic, 14-day forced-swim stress testing blocked the immobility-decreasing effect induced by a single administration of imipramine. When imipramine was administered for 14 days concurrently with forced-swim stress testing, immobility was shortened significantly. From the viewpoint of imipramine's effect, these findings suggest that chronic forced-swim stress testing in rats may be an effective animal model for depression.
我们研究了丙咪嗪对慢性强迫游泳应激大鼠不动时间的影响。在强迫游泳测试中，单次和长期给予丙咪嗪均能显著缩短正常大鼠的不动时间。然而，为期14天的慢性强迫游泳应激测试阻断了单次给予丙咪嗪所诱导的不动时间缩短效应。当丙咪嗪与强迫游泳应激测试同时给药14天时，不动时间显著缩短。从丙咪嗪的作用角度来看，这些发现表明大鼠慢性强迫游泳应激测试可能是一种有效的抑郁症动物模型。
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