Dobrilla G, Piazzi L, Amplatz S, Benvenuti S, Di Fede F
Divisione di Gastroenterologia, Ospedale Generale Regionale, Bolzano, Italy.
Ital J Gastroenterol. 1992 Feb;24(2):79-84.
The relationship between Helicobacter pylori (HP) and gastric ulcer therapy is examined by analyzing both the data that suggest that eradication of HP renders the gastric mucosa less susceptible to development of gastric ulcer as well as the substantial body of evidence that does not support this contention. The results reported in clinical trials with colloidal bismuth citrate, antimicrobial agents (furazolidone), and combinations of anti-ulcer and antimicrobial agents (H2-antagonist+cefixime, H2-antagonist+metronidazole) are reviewed. Also analyzed is the relationship between HP eradication and ulcer recurrence. Only one study is available on this aspect, and the limited evidence it provides in favour of a prophylactic effect of eradication therapy is not entirely convincing. The authors conclude that there is no reasonable case for the dogmatic assumption that eradication of HP facilitates either acute healing or long-term prophylaxis of gastric ulcer, though certain subgroups of gastric ulcer patients may benefit from eradication therapy.
通过分析表明根除幽门螺杆菌（HP）可使胃黏膜对胃溃疡的发生不那么敏感的数据，以及大量不支持这一论点的证据，来研究幽门螺杆菌（HP）与胃溃疡治疗之间的关系。回顾了用胶体枸橼酸铋、抗菌剂（呋喃唑酮）以及抗溃疡和抗菌剂组合（H2拮抗剂+头孢克肟、H2拮抗剂+甲硝唑）进行的临床试验报告的结果。还分析了根除HP与溃疡复发之间的关系。关于这方面只有一项研究，它所提供的支持根除疗法具有预防作用的有限证据并不完全令人信服。作者得出结论，虽然某些胃溃疡患者亚组可能从根除疗法中获益，但教条地假设根除HP有助于胃溃疡的急性愈合或长期预防是没有合理依据的。
