Pisarek H, Stepien H
Institute of Endocrinology, Medical Academy of Lodz, Poland.
Histol Histopathol. 1992 Jan;7(1):111-7.
Mesulergine (Cu32-085) is an active semisynthetic ergot alkaloid with unusual biphasic antagonistic-agonistic effect on dopamine (DA) turnover in the rat striatum. The present study has been made to elucidate the influence of the long-term treatment of this drug on prolactin secretion and prolactin cells morphology in the female Wistar rats with experimentally-induced hyperprolactinemia. Additionally, the effect of this drug was compared with bromocriptine and pergolide activity, applied in the same experimental conditions. It has been shown that prolonged mesulergine treatment attenuated the stimulatory effect of stilboestrol on prolactin secretion in vivo. It also decreased mean prolactin cells density, above all cells and lactotroph mitotic indexes, estimated in immunohistochemically-stained slides. However, antiproliferative activity of Cu 32-085 was weaker, when compared with bromocriptine and pergolide.
美舒麦角（Cu32 - 085）是一种活性半合成麦角生物碱，对大鼠纹状体中的多巴胺（DA）代谢具有不寻常的双相拮抗 - 激动作用。本研究旨在阐明长期使用该药物对实验性诱导的高催乳素血症雌性Wistar大鼠催乳素分泌和催乳素细胞形态的影响。此外，将该药物的作用与在相同实验条件下应用的溴隐亭和培高利特的活性进行了比较。结果表明，长期使用美舒麦角可减弱己烯雌酚对体内催乳素分泌的刺激作用。它还降低了平均催乳素细胞密度，尤其是免疫组织化学染色切片中估计的细胞和促乳素细胞有丝分裂指数。然而，与溴隐亭和培高利特相比，Cu 32 - 085的抗增殖活性较弱。
