Croucher P I, Wright C D, Garrahan N J, Kudlac H, Williams A J, Compston J E
Department of Pathology, University of Wales College of Medicine, Cardiff, UK.
Bone Miner. 1992 Feb;16(2):139-7. doi: 10.1016/0169-6009(92)90884-g.
Using a computerised technique, resorption cavity characteristics in iliac crest trabecular bone were assessed in 30 patients with chronic renal failure and compared with data obtained from healthy subjects. The mean and maximum cavity depth were significantly greater in the patient group (P less than 0.0001); in addition, cavity area, the percentage of bone being remodelled, the number of cavities per mm trabecular surface and the percentage eroded surface were all significantly greater than in controls (P less than 0.0001). However, the surface length of individual cavities in the patient group did not differ significantly from that of controls. In the patient group, serum intact parathyroid hormone concentrations showed a significant positive correlation with mean resorption cavity depth (r = 0.451, P less than 0.05). Our results demonstrate that the increase in bone resorption associated with hyperparathyroidism secondary to chronic renal failure is due to an increase both in the number and depth of cavities, although the surface extent of individual cavities is normal. These findings indicate that factors determining the length of trabecular surface eroded and the depth of individual resorption cavities are controlled by different mechanisms.
采用计算机技术，对30例慢性肾衰竭患者髂嵴小梁骨的吸收腔特征进行评估，并与健康受试者的数据进行比较。患者组的平均腔深和最大腔深显著更大（P<0.0001）；此外，腔面积、骨重塑百分比、每毫米小梁表面的腔数以及侵蚀表面百分比均显著大于对照组（P<0.0001）。然而，患者组单个腔的表面长度与对照组相比无显著差异。在患者组中，血清完整甲状旁腺激素浓度与平均吸收腔深度呈显著正相关（r = 0.451，P<0.05）。我们的结果表明，慢性肾衰竭继发甲状旁腺功能亢进相关的骨吸收增加是由于腔的数量和深度均增加，尽管单个腔的表面范围正常。这些发现表明，决定小梁表面侵蚀长度和单个吸收腔深度的因素受不同机制控制。
