Mbulaiteye Sam M, Biggar Robert J, Pfeiffer Ruth M, Bakaki Paul M, Gamache Christine, Owor Anchilla M, Katongole-Mbidde Edward, Ndugwa Christopher M, Goedert James J, Whitby Denise, Engels Eric A
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Department of Health and Human Services, Rockville, MD 20852, USA.
J Acquir Immune Defic Syndr. 2005 Apr 1;38(4):474-9. doi: 10.1097/01.qai.0000132495.89162.c0.
Human herpesvirus 8 (HHV-8) infection is common in sub-Saharan Africa, but its distribution is uneven. Transmission occurs during childhood within families by unclear routes.
We evaluated 600 Ugandan children with sickle cell disease and their mothers for factors associated with HHV-8 seropositivity in a cross-sectional study. HHV-8 serostatus was determined using an HHV-8 K8.1 glycoprotein enzyme immunoassay. Odds ratios for seropositivity were estimated using logistic regression, and factor analysis was used to identify clustering among socioeconomic variables.
One hundred seventeen (21%) of 561 children and 166 (34%) of 485 mothers with definite HHV-8 serostatus were seropositive. For children, seropositivity was associated with age, mother's HHV-8 serostatus (especially for children aged 6 years or younger), lower maternal education level, mother's income, and low-status father's occupation (P < 0.05 for all). Using communal standpipe or using surface water sources were both associated with seropositivity (OR 2.70, 95% CI 0.80-9.06 and 4.02, 95% CI 1.18-13.7, respectively) as compared to using private tap water. These associations remained, albeit attenuated, after adjusting for maternal education and child's age (P = 0.08). In factor analysis, low scores on environmental and family factors, which captured household and parental characteristics, respectively, were positively associated with seropositivity (P(trend) < 0.05 for both). For mothers, HHV-8 seropositivity was significantly associated with water source and maternal income.
HHV-8 infection in Ugandan children was associated with lower socioeconomic status and using surface water. Households with limited access to water may have less hygienic practices that increase risk for HHV-8 infection.
人类疱疹病毒8型（HHV - 8）感染在撒哈拉以南非洲很常见，但其分布不均衡。感染在儿童期通过不明确的途径在家庭内传播。
在一项横断面研究中，我们评估了600名患有镰状细胞病的乌干达儿童及其母亲中与HHV - 8血清阳性相关的因素。使用HHV - 8 K8.1糖蛋白酶免疫测定法确定HHV - 8血清状态。使用逻辑回归估计血清阳性的比值比，并使用因子分析来识别社会经济变量之间的聚类。
在561名有明确HHV - 8血清状态的儿童中，117名（21%）血清呈阳性；在485名有明确HHV - 8血清状态的母亲中，166名（34%）血清呈阳性。对于儿童，血清阳性与年龄、母亲的HHV - 8血清状态（特别是6岁及以下儿童）、母亲教育水平较低、母亲收入以及父亲低地位职业相关（所有P < 0.05）。与使用私人自来水相比，使用公共立管或使用地表水水源均与血清阳性相关（比值比分别为2.70，95%可信区间0.80 - 9.06和4.02，95%可信区间1.18 - 13.7）。在调整母亲教育程度和儿童年龄后，这些关联仍然存在，尽管有所减弱（P = 0.08）。在因子分析中，分别反映家庭和父母特征的环境和家庭因素得分较低与血清阳性呈正相关（两者趋势P < 0.05）。对于母亲，HHV - 8血清阳性与水源和母亲收入显著相关。
乌干达儿童的HHV - 8感染与较低的社会经济地位和使用地表水有关。获得水有限的家庭可能卫生习惯较差，增加了HHV - 8感染风险。
