Kato Naoko, Nonaka Nariaki, Oku Yuzaburo, Kamiya Masao
Laboratory of Parasitology, Department of Disease Control, Graduate School of Veterinary Medicine, Hokkaido University, 060-0818 Sapporo, Japan.
Parasitol Res. 2005 Apr;96(1):12-7. doi: 10.1007/s00436-005-1307-9. Epub 2005 Mar 12.
Immune responses to oral infection with Echinococcus multilocularis protoscoleces in Mongolian gerbils were investigated. Gerbils not treated with prednisolone expelled most of the parasites within 3 days post-infection and induced parasite-specific intestinal IgA secretion after the oral inoculation with protoscoleces. In contrast, prednisolone-treated gerbils harbored notable numbers of parasites, and the parasite-specific intestinal IgA secretion was lower. In gerbils not treated and orally inoculated with protoscoleces (infected group), parasite-specific antibody levels in sera and intestinal washings were elevated, but blastogenesis against protoscolex antigens was observed only in cells from Peyer's patches at 14 days post-infection. Concanavalin A-induced proliferative lymphocytes from both infected and naive gerbils were suppressed by adding protoscolex somatic antigen. These data indicate that while parasite-specific antibody responses were observed, lymphocyte proliferative responses were suppressed by parasite infection/antigens in the Mongolian gerbil, prednisolone-untreated rodent definitive host model.
研究了蒙古沙鼠对多房棘球绦虫原头节口服感染的免疫反应。未用泼尼松龙治疗的沙鼠在感染后3天内排出了大部分寄生虫，并在口服接种原头节后诱导了寄生虫特异性肠道IgA分泌。相比之下，用泼尼松龙治疗的沙鼠体内寄生着大量寄生虫，且寄生虫特异性肠道IgA分泌较低。在未治疗且口服接种原头节的沙鼠（感染组）中，血清和肠道冲洗液中的寄生虫特异性抗体水平升高，但仅在感染后14天观察到派伊尔结细胞对原头节抗原的增殖反应。添加原头节体抗原可抑制感染和未感染沙鼠的伴刀豆球蛋白A诱导的淋巴细胞增殖。这些数据表明，在蒙古沙鼠（未用泼尼松龙治疗的啮齿类终末宿主模型）中，虽然观察到了寄生虫特异性抗体反应，但寄生虫感染/抗原抑制了淋巴细胞增殖反应。
