Janas Robert, Gburek Tadeusz, Cisowski Marek, Wilczyński Mirosław, Białkowska Bozena, Bochenek Andrzej
I Kliniki Kardiochirurgii, Slaskiej Akademii Medycznej w Katowicach.
Wiad Lek. 2004;57(9-10):413-20.
Aim of the study was to evaluate retrospectively recent and late results of coronary artery bypass grafting (CABG) in patients with ischaemic heart disease and severe left ventricular dysfunction. 146 patients (125 men, 21 women) aged 58.4 +/- 8.4 years, with angina (Canadian Cardiac Society--CCS class > or = 1), heart failure (New York Heart Association--NYHA class > or = 1), left ventricular ejection fraction (LVEF < or = 30%), multi-vessel coronary disease were included to the study. All patients underwent CABG. Peri-operative mortality was 6.1%, in-hospital mortality was 8.2%, 1-year survival was 86.5% and 4-year survival--80%. It was shown that CABG improves angina, dyspnoea and LVEF in patients with coronary heart disease and depressed left ventricle function (LVEF < or = 30%). Selected parameters like: unstable angina requiring intra-aortic balloon pump (IABP) preoperatively, recent heart infarction, cerebrovascular disease, severly depressed left ventricle function (LVEF < or = 20%), mitral regurgitation and Cleveland score > or = 10 pts significantly influence early surgical results (up to 30 days after surgery). It was shown that independent parameters predicting long-term survival and risk of major cardiac events were: negative dobutamine stress test, significant mitral valve incompetence and Cleveland score > or = 10 pts. Use of crystalloid cardioplegia increases early risk of CABG however none of methods of myocardial protection affects long-term surgical results. The outcomes of procedures using blood cardioplegia or intermittent cross clamp and ventricular fibrillation are comparable.
本研究的目的是回顾性评估缺血性心脏病和严重左心室功能不全患者冠状动脉旁路移植术(CABG)的近期和远期结果。146例患者(125例男性,21例女性),年龄58.4±8.4岁,有胸痛(加拿大心血管学会——CCS分级≥1级)、心力衰竭(纽约心脏协会——NYHA分级≥1级)、左心室射血分数(LVEF≤30%)、多支冠状动脉病变,纳入本研究。所有患者均接受了CABG。围手术期死亡率为6.1%,住院死亡率为8.2%,1年生存率为86.5%,4年生存率为80%。结果表明,CABG可改善冠心病和左心室功能降低(LVEF≤30%)患者的胸痛、呼吸困难和LVEF。一些选定参数,如术前需要主动脉内球囊反搏(IABP)的不稳定型心绞痛、近期心肌梗死、脑血管疾病、严重左心室功能降低(LVEF≤20%)、二尖瓣反流和克利夫兰评分≥10分,对早期手术结果(术后30天内)有显著影响。结果表明,预测长期生存和主要心脏事件风险的独立参数为:多巴酚丁胺负荷试验阴性、明显二尖瓣关闭不全和克利夫兰评分≥10分。使用晶体心脏停搏液会增加CABG的早期风险,然而,心肌保护方法均不影响长期手术结果。使用血液心脏停搏液或间歇性阻断夹闭和心室颤动的手术结果相当。