Fontana Margherita, Zunt Susan, Eckert George J, Zero Domenick
Department of Preventive Dentistry, Oral Health Research Institute, Indianapolis, IN 46202, USA.
Oper Dent. 2005 Jan-Feb;30(1):3-8.
It is well established that saliva is an important factor for the health of both soft and hard tissues in the oral cavity. This study determined: 1) the correlation between unstimulated salivary flow assessed using the Modified Schirmer tear strip Test (MST), with gravimetric and volumetric measurements and 2) the MST value that would allow the most reliable identification of patients with severe (<0.1 ml/minute) and moderate (<0.2 ml/minute) hyposalivation. A retrospective clinical study was conducted using data from 90 patients seen at the Indiana University School of Dentistry. All patients had a sample of unstimulated whole saliva collected by drooling for five minutes for volumetric/gravimetric assessment, followed by placement of the Schirmer strip in the floor of the mouth for three minutes (MST). Results showed a non-linear association between the MST and volumetric/gravimetric methods, with moderate Spearman correlation coefficients (0.67-0.71). Analysis of ROC-curves suggests that a cutoff screening value of 25 mm/three minutes provides high sensitivity (77%) and positive predictive value (71%) without significantly affecting specificity (80%). In conclusion, this study supports use of the MST test as a screening tool for hyposalivation.
唾液是口腔软硬组织健康的重要因素，这一点已得到充分证实。本研究确定了：1）使用改良式Schirmer泪液条试验（MST）评估的非刺激性唾液流量与重量法和容量法测量之间的相关性；2）能够最可靠地识别重度（<0.1毫升/分钟）和中度（<0.2毫升/分钟）唾液分泌减少患者的MST值。利用印第安纳大学牙科学院90例患者的数据进行了一项回顾性临床研究。所有患者均收集了一份非刺激性全唾液样本，通过流口水5分钟进行容量/重量评估，然后将Schirmer试纸条置于口腔底部3分钟（MST）。结果显示MST与容量/重量法之间存在非线性关联，Spearman相关系数中等（0.67 - 0.71）。ROC曲线分析表明，25毫米/3分钟的截断筛查值具有高敏感性（77%）和阳性预测值（71%），且不会显著影响特异性（80%）。总之，本研究支持将MST试验用作唾液分泌减少的筛查工具。
