Segura-Flores Aída Alejandra, Gálvez-Gastélum Francisco Javier, Alvarez-Rodríguez Adriana, Armendáriz-Borunda Juan
Instituto de Biología Molecular y Terapia Génica, Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Guadalajara, Jalisco.
Rev Gastroenterol Mex. 2004 Oct-Dec;69(4):243-50.
Hepatocyte growth factor (HGF) also known as "scatter factor" (SF), was identified for the first time as a potent mitogen of primary cultured hepatocytes; it has multiple biological responses in a variety of cells including mitogenic, motogenic, morphogenic and antiapoptotic activities. It is secreted as an inactive single chain protein and isproteolitically cleaved to form an active two chain HGF. The hepatocyte growth factor activator (HGFA) is the principal activator of HGF. HGF exerts its biological effects through transmembrane tyrosine kinase receptor (c-Met). HGF is a growth factor displaying a remarkable ability to promote tissue repair and organ regeneration after injury. Therefore attention should be set on the clinical potential of HGF as a treatment for various diseases.
肝细胞生长因子（HGF）也被称为“分散因子”（SF），首次被鉴定为原代培养肝细胞的一种强效促有丝分裂剂；它在多种细胞中具有多种生物学反应，包括促有丝分裂、促运动、形态发生和抗凋亡活性。它以无活性的单链蛋白形式分泌，并经蛋白水解切割形成有活性的双链HGF。肝细胞生长因子激活剂（HGFA）是HGF的主要激活剂。HGF通过跨膜酪氨酸激酶受体（c-Met）发挥其生物学效应。HGF是一种生长因子，在损伤后具有促进组织修复和器官再生的显著能力。因此，应关注HGF作为治疗各种疾病的临床潜力。
