抗神经节苷脂抗体在小鼠实验性布氏锥虫感染中的作用。
Effect of anti-ganglioside antibody in experimental Trypanosoma brucei infection in mice.
作者信息
Tsujimura Yoshie, Watarai Shinobu, Uemura Akiko, Ohnishi Yoshihiro, Kodama Hiroshi
机构信息
Laboratory of Veterinary Immunology, Division of Veterinary Science, Graduate School of Agriculture and Biological Sciences, Osaka Prefecture University, 1-1 Gakuen-cho, Sakai, Osaka 599-8531, Japan.
出版信息
Res Vet Sci. 2005 Jun;78(3):245-7. doi: 10.1016/j.rvsc.2004.09.003.
The effect of antibody against ganglioside antigen on Trypanosoma brucei parasites was examined in vitro and in vivo using anti-ganglioside GM1 (AGM-1) monoclonal antibody. The antibody showed complement-dependent cytotoxicity against T. brucei with mouse complement. Furthermore, mice given AGM-1 were challenged intraperitoneally with T. brucei. Although all non-treated control mice died within six days after infection, all of AGM-1-injected mice had survived by six days post-infection. These data suggest that antibody against ganglioside antigen on T. brucei has potential in protection against T. brucei infection.
使用抗神经节苷脂GM1（AGM-1）单克隆抗体在体外和体内检测了抗神经节苷脂抗原抗体对布氏锥虫寄生虫的作用。该抗体对布氏锥虫与小鼠补体表现出补体依赖性细胞毒性。此外，给注射AGM-1的小鼠腹腔注射布氏锥虫进行攻毒。尽管所有未处理的对照小鼠在感染后六天内死亡，但所有注射AGM-1的小鼠在感染后六天仍存活。这些数据表明，针对布氏锥虫神经节苷脂抗原的抗体在预防布氏锥虫感染方面具有潜力。
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