Nagata Chisato, Nagao Yasuko, Shibuya Chiken, Kashiki Yoshitomo, Shimizu Hiroyuki
Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, Gifu, Japan.
Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):705-8. doi: 10.1158/1055-9965.EPI-04-0619.
Recent laboratory studies have suggested that cadmium is an estrogenic compound and may be a potential risk factor for breast cancer.
We investigated the relationship between urinary cadmium concentrations and serum concentrations of estrone, testosterone, and dehydroepiandrosterone sulfate in 164 postmenopausal Japanese women.
There was a significant positive association between the urinary cadmium and serum testosterone levels after controlling for age and body mass index. The mean testosterone level was 28% higher in women with high urinary cadmium (> or = 3.00 microg/g creatinine) than in those with low urinary cadmium (< 2.00 microg/g creatinine). Urinary cadmium was not significantly associated with serum estrone and dehydroepiandrosterone sulfate levels. Additional adjustment for smoking, alcohol and reproductive factors including known risk factors for breast cancer did not substantially alter the results.
Data suggested that cadmium exposure is associated with increased testosterone levels. As high testosterone levels have been associated with the risk of breast cancer, the involvement of cadmium exposure in breast cancer risk should be evaluated in future studies.
近期的实验室研究表明，镉是一种雌激素类化合物，可能是乳腺癌的潜在风险因素。
我们调查了164名绝经后日本女性尿镉浓度与血清雌酮、睾酮及硫酸脱氢表雄酮浓度之间的关系。
在控制年龄和体重指数后，尿镉与血清睾酮水平之间存在显著正相关。尿镉水平高（≥3.00微克/克肌酐）的女性，其平均睾酮水平比尿镉水平低（<2.00微克/克肌酐）的女性高28%。尿镉与血清雌酮及硫酸脱氢表雄酮水平无显著关联。对吸烟、饮酒及包括已知乳腺癌风险因素在内的生殖因素进行进一步校正后，结果基本未变。
数据表明，镉暴露与睾酮水平升高有关。由于高睾酮水平与乳腺癌风险相关，未来研究应评估镉暴露与乳腺癌风险之间的关联。
