Stumpf Michael P H, Wiuf Carsten, May Robert M
Centre for Bioinformatics, Imperial College London, Wolfson Building, London SW7 2AZ, UK.
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4221-4. doi: 10.1073/pnas.0501179102. Epub 2005 Mar 14.
Most studies of networks have only looked at small subsets of the true network. Here, we discuss the sampling properties of a network's degree distribution under the most parsimonious sampling scheme. Only if the degree distributions of the network and randomly sampled subnets belong to the same family of probability distributions is it possible to extrapolate from subnet data to properties of the global network. We show that this condition is indeed satisfied for some important classes of networks, notably classical random graphs and exponential random graphs. For scale-free degree distributions, however, this is not the case. Thus, inferences about the scale-free nature of a network may have to be treated with some caution. The work presented here has important implications for the analysis of molecular networks as well as for graph theory and the theory of networks in general.
大多数网络研究仅着眼于真实网络的小子集。在此,我们讨论在最简约抽样方案下网络度分布的抽样特性。只有当网络和随机抽样子网的度分布属于同一概率分布族时,才有可能从子网数据推断全局网络的特性。我们表明,对于某些重要的网络类别,特别是经典随机图和指数随机图,这一条件确实得到满足。然而,对于无标度度分布而言,情况并非如此。因此,关于网络无标度性质的推断可能必须谨慎对待。本文所呈现的工作对分子网络分析以及一般的图论和网络理论都具有重要意义。