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[1例甲状旁腺癌合并严重骨骼受累的原发性甲状旁腺功能亢进症]

[Primary hyperparathyroidism with severe skeletal involvement in one patient with parathyroid carcinoma].

作者信息

Ríos S Lorena, Sapunar Z Jorge, Roa E Iván

机构信息

Unidad de Endocrinología, Departamento de Medicina Interna, Facultad de Medicina, Universidad de la Frontera.

出版信息

Rev Med Chil. 2005 Jan;133(1):77-81. doi: 10.4067/s0034-98872005000100010. Epub 2005 Mar 10.

Abstract

Parathyroid carcinoma is an uncommon cause of primary hyperparathyroidism; however, when this condition is severe, cancer must be suspected. We report on a 28-year-old male with severe hypercalcemia, cachexia, acute pancreatitis, urolithiasis, anemia and a severe skeletal involvement with multiple fractures. The patient had a 4-cm parathyroid tumor, that was surgically excised, along with the ipsilateral thyroid lobe. During the postoperative period, he had a severe and prolonged hungry bone syndrome, with a slow recovery of fractures, with functional and anatomical sequelae in the extremities. PTH levels were adequate for the serum calcium during the 16 months of follow-up.

摘要

甲状旁腺癌是原发性甲状旁腺功能亢进的罕见病因;然而,当病情严重时,必须怀疑为癌症。我们报告一例28岁男性,患有严重高钙血症、恶病质、急性胰腺炎、尿路结石、贫血以及严重的骨骼受累并伴有多处骨折。该患者有一个4厘米的甲状旁腺肿瘤,连同同侧甲状腺叶一起被手术切除。术后期间,他出现了严重且持续时间较长的饥饿骨综合征,骨折愈合缓慢,四肢出现功能和解剖学后遗症。在16个月的随访期间,甲状旁腺激素水平与血清钙水平相适应。

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