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人血浆中蛋白C的昼夜节律——肝脏自主功能的有用标志物。

Circadian rhythm of protein C in human plasma--useful marker of autonomic function in liver.

作者信息

Obayashi Konen, Hanyu Osamu, Miida Takashi, Ando Yukio, Nakamura Masaaki, Zhu Ying, Okada Masahiko

出版信息

Clin Auton Res. 2005 Feb;15(1):57-8. doi: 10.1007/s10286-005-0219-1.

DOI:10.1007/s10286-005-0219-1
PMID:15768205
Abstract

We have demonstrated changes in the circadian rhythm of plasma protein C levels in patients with autonomic dysfunction and liver-transplanted patients, compared with that in healthy volunteers. The circadian rhythm of protein C serves as a useful marker to screen for autonomic dysfunction in the liver.

摘要

与健康志愿者相比，我们已经证明自主神经功能障碍患者和肝移植患者血浆蛋白C水平的昼夜节律发生了变化。蛋白C的昼夜节律可作为筛查肝脏自主神经功能障碍的有用标志物。

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本文引用的文献

1
Circadian variations in natural coagulation inhibitors protein C, protein S and antithrombin in healthy men: a possible association with interleukin-6.健康男性体内天然凝血抑制剂蛋白C、蛋白S和抗凝血酶的昼夜变化：与白细胞介素-6的可能关联。
Thromb Haemost. 1999 Apr;81(4):571-5.
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Autonomic dysfunction in familial amyloidotic polyneuropathy (FAP).家族性淀粉样多神经病（FAP）中的自主神经功能障碍。
Amyloid. 1998 Dec;5(4):288-300. doi: 10.3109/13506129809007303.
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Regulation of hepatic glucose production during exercise in humans: role of sympathoadrenergic activity.
运动期间人体肝脏葡萄糖生成的调节：交感神经活性的作用。
Am J Physiol. 1993 Aug;265(2 Pt 1):E275-83. doi: 10.1152/ajpendo.1993.265.2.E275.
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Can J Physiol Pharmacol. 1980 Feb;58(2):105-23. doi: 10.1139/y80-019.
6
Protein C, an antithrombotic protein, is reduced in hospitalized patients with intravascular coagulation.蛋白C是一种抗血栓形成蛋白，在患有血管内凝血的住院患者中含量降低。
Blood. 1982 Jul;60(1):261-4.
7
Anticoagulant properties of bovine plasma protein C following activation by thrombin.凝血酶激活后牛血浆蛋白C的抗凝特性。
Biochemistry. 1977 Dec 27;16(26):5824-31. doi: 10.1021/bi00645a029.