Flanigan Timothy P, Taylor Lynn E, Mitty Jennifer A
Department of Medicine, The Miriam Hospital, Brown University School of Medicine, Providence, Rhode Island 02906, USA.
Clin Infect Dis. 2005 Apr 15;40 Suppl 5:S346-8. doi: 10.1086/427451.
Directly observed therapy (DOT) is an effective approach for the treatment of tuberculosis among substance users. We have adapted this model to treat human immunodeficiency virus infection. Our experience suggests that community-based, modified DOT should be explored further as a means to treat infectious diseases and chronic medical illnesses for persons with drug dependence; it may be especially pertinent for the treatment of hepatitis C virus infection. DOT can both optimize adherence and provide a way to offer psychosocial support and linkages to social, addiction, psychiatric, and other services, to help address many of the challenges faced by persons with substance abuse disorders.
直接观察治疗（DOT）是治疗药物使用者结核病的一种有效方法。我们已对该模式进行调整，用于治疗人类免疫缺陷病毒感染。我们的经验表明，应进一步探索基于社区的改良DOT，作为治疗药物依赖者传染病和慢性疾病的一种手段；它可能对丙型肝炎病毒感染的治疗尤为适用。DOT既能优化依从性，又能提供一种方式，来提供心理社会支持以及与社会、成瘾、精神科和其他服务的联系，以帮助应对药物滥用障碍患者面临的许多挑战。
