Occhipinti Elise, Heinrich Stephen D, Craver Randall
Department of Pathology, Louisiana State Uiversity Health Sciences Center, New Orland, Louisiana, USA.
Fetal Pediatr Pathol. 2004 Mar-Jun;23(2-3):171-9. doi: 10.1080/15227950490890441.
Giant cell tumor of the tendon sheath (nodular synovitis) is a benign soft tissue tumor, usually affecting older women, that most often occurs in the interphalangeal joints of the fingers. Occurrence is rare in children. We present a 12-year-old boy and a 6-year-old girl with giant cell tumors of tendon sheaths occurring in the toes. The tumor from the 12-year-old demonstrated the cytogenetic finding of t(1;2)(p13;q37), which previously has been associated with giant cell tumor of tendon sheath in adults. Giant cell tumors of the tendon sheath occurring in children have similar histological and cytogenetic features as adults, however, there may be a predilection for lower extremity involvement.
腱鞘巨细胞瘤（结节性滑膜炎）是一种良性软组织肿瘤，通常影响老年女性，最常发生于手指的指间关节。在儿童中发病率较低。我们报告了一名12岁男孩和一名6岁女孩，他们的腱鞘巨细胞瘤发生在脚趾。12岁男孩的肿瘤显示出细胞遗传学发现t(1;2)(p13;q37)，这一发现先前已在成人腱鞘巨细胞瘤中出现。儿童发生的腱鞘巨细胞瘤与成人具有相似的组织学和细胞遗传学特征，然而，可能更倾向于累及下肢。
