Wang Sheng, Ji Hong-yan, Zhang Nian-zhi, Zhuo Xiu-zhen, Zhao Li-ping, Zhu Hui-zhi, Chen Wei, Ren Wei
Respiratory Department, the First Affiliated Hospital to Anhui College of TCM, Hefei 230031.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2005 Feb;25(2):111-3.
To explore the effect and the mechanism of yifei jianpi recipe (YFJPR) on patients with chronic obstructive pulmonary disease (COPD).
Forty patients with COPD in stable phase were randomly divided into two groups, the treated group and the control group. Indexes including the total and differential count of inflammatory cell in sputum, levels of interleukin-8 (IL-8) and tumor necrosis factor-alpha (TNF-alpha), as well as the percentage of forced expiratory volume in one second in its predicted value (FEV1%) and ratio of FEV1/forced vital capacity (FVC) in patients were measured before and after treatment, and compared with those in 20 healthy subjects.
All the indexes measured in patients before and after treatment were significantly different from those in healthy subjects (P < 0.01). Differential count of polymorphonuclear neutrophil (PMN) and levels of IL-8 and TNF-alpha in sputum in the treated group significantly decreased after treatment (P < 0.01), while the non-PMN differential count and levels of FEV1% and FEV1/FVC significantly increased (P < 0.01). But in the control group, changes only showed in increasing of FEV1% and FEV1/FVC (P < 0.05 or P < 0.01). And the effects in the treated group were better than those in the control group (P < 0.01).
YFJPR can play a therapeutic role on patients with COPD by way of reducing the airway inflammatory reaction.
探讨益肺健脾方（YFJPR）对慢性阻塞性肺疾病（COPD）患者的疗效及作用机制。
将40例稳定期COPD患者随机分为治疗组和对照组。检测患者治疗前后痰液中炎症细胞总数及分类计数、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）水平，以及一秒用力呼气容积占预计值百分比（FEV1%）和FEV1/用力肺活量比值（FVC），并与20例健康受试者进行比较。
患者治疗前后各项检测指标与健康受试者相比均有显著差异（P<0.01）。治疗组治疗后痰液中多形核中性粒细胞（PMN）分类计数及IL-8、TNF-α水平显著降低（P<0.01），而非PMN分类计数及FEV1%、FEV1/FVC显著升高（P<0.01）。对照组仅FEV1%和FEV1/FVC有所升高（P<0.05或P<0.01）。且治疗组疗效优于对照组（P<0.01）。
益肺健脾方可通过减轻气道炎症反应对COPD患者发挥治疗作用。
